The Wicked + The Divine has the feeling of Neil Gaiman's "American Gods" in graphic novel format.

Every 90 years an assortment of gods reincarnates, their essence bonding with mortal men and women, once again able to step into the world. But like most things there is a catch. Only twelve of them appear at any one time, and they live for only two years.

The Wicked + The Divine brings a new brew of mythology by blending sci-fi and fantasy elements with a millennial touch. The story starts with twelve gods reincarnated as young adults after facing their last ninety-year cycle. They become different breeds of new age popstars, flashy symbols of magical powers and fake immortality, since they only have two years to live in their young bodies. They’re either worshiped or hated by followers in the Digital Age (the first issue briefly starts on December 31, 1924 then jumps to 2014 and on for the rest of the series). References to all things mainstream from our current generation aren’t off limits: yes, these deities tweet and hashtag. Despite creating a collective of characters in the image of classical mythology, humanity isn’t an afterthought in this series.

Definitely worth a fun read, and it definitely has potential for a game setting

that does sound like a good read and definitely a game setting.